Severe experimental uraemia does not decrease the population of rat pituitary somatotrophs
نویسندگان
چکیده
منابع مشابه
Severe experimental uraemia does not decrease the population of rat pituitary somatotrophs.
BACKGROUND Growth hormone (GH) secretion by the anterior pituitary has been shown to be depressed in severely uraemic rats. Changes in the population of pituitary somatotrophs might be partially responsible for this decrease. METHODS To analyse the population of pituitary somatotrophs in severe uraemia, immunocytochemical detection and quantification of GH-producing cells were carried out on ...
متن کاملCinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia.
BACKGROUND Cinacalcet (CIN) efficiently suppresses parathyroid hormone (PTH) secretion by the activation of the calcium-sensing receptor (CaR). Epiphyseal chondrocytes also express the CaR and its activation promotes cell proliferation and differentiation in vitro. Hence, the impact of CIN on the growth plate function requires assessment before routine administration in children. METHODS We t...
متن کاملPhysically Active Lifestyle Does Not Decrease the Risk of Fattening
BACKGROUND Increasing age is associated with declining physical activity and a gain in fat mass. The objective was to observe the consequence of the age-associated reduction in physical activity for the maintenance of energy balance as reflected in the fat store of the body. METHODOLOGY/PRINCIPAL FINDINGS Young adults were observed over an average time interval of more than 10 years. Physical...
متن کاملExperimental arthritis in the rat does not alter the analgesic potency of intrathecal or intraarticular morphine.
UNLABELLED To explore further the role of inflammatory processing on peripheral opioid pharmacology, we examined whether the potency of intraarticular (i.a.) or intrathecal (i.t) morphine in tests of thermal and mechanical nociception changed during the induction of experimental arthritis in the rat. Thermal nociception by i.t. morphine (3, 10, and 50 micrograms) or i.a. morphine (100, 1000, an...
متن کاملCaecal pH and ammonia in experimental uraemia.
Urea is freely diffusible from the blood into the lumen of the alimentary tract, where it is converted by the enzyme urease into ammonia and CO2. Tracer studies indicate that at least 25% of the urea in the body undergoes hydrolysis within the gut (Walser and Bodenlos, 1959), but a proportion of the ammonia produced is absorbed and re-synthesized to urea in the liver. The practical importance o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 1998
ISSN: 1460-2385
DOI: 10.1093/ndt/13.10.2563